Literature DB >> 1237925

Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

B Hine, M Torrelio, S Gershon.   

Abstract

The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.

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Year:  1975        PMID： 1237925

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  9 in total

1.  The impact of naturalistic cannabis use on self-reported opioid withdrawal.

Authors:  Cecilia L Bergeria; Andrew S Huhn; Kelly E Dunn
Journal:  J Subst Abuse Treat       Date:  2020-03-30

2.  Cannabidiol regulates behavioural alterations and gene expression changes induced by spontaneous cannabinoid withdrawal.

Authors:  Francisco Navarrete; Auxiliadora Aracil-Fernández; Jorge Manzanares
Journal:  Br J Pharmacol       Date:  2018-05-03       Impact factor: 8.739

3.  High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis.

Authors:  Maria Eugenia Socías; Evan Wood; Stephanie Lake; Seonaid Nolan; Nadia Fairbairn; Kanna Hayashi; Hennady P Shulha; Seagle Liu; Thomas Kerr; M-J Milloy
Journal:  Addiction       Date:  2018-09-20       Impact factor: 6.526

Review 4.  Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence.

Authors:  Kelly E Dunn; Andrew S Huhn; Cecilia L Bergeria; Cassandra D Gipson; Elise M Weerts
Journal:  J Pharmacol Exp Ther       Date:  2019-08-07       Impact factor: 4.030

Review 5.  Cannabidiol and substance use disorder: Dream or reality.

Authors:  Saeideh Karimi-Haghighi; Yasaman Razavi; Daniela Iezzi; Andrew F Scheyer; Olivier Manzoni; Abbas Haghparast
Journal:  Neuropharmacology       Date:  2022-01-13       Impact factor: 5.273

Review 6.  Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?

Authors:  Natalie E Zlebnik; Joseph F Cheer
Journal:  Annu Rev Neurosci       Date:  2016-02-24       Impact factor: 12.449

Review 7.  Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.

Authors:  Yasmin L Hurd; Michelle Yoon; Alex F Manini; Stephanie Hernandez; Ruben Olmedo; Maria Ostman; Didier Jutras-Aswad
Journal:  Neurotherapeutics       Date:  2015-10       Impact factor: 7.620

Review 8.  Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence.

Authors:  Mélissa Prud'homme; Romulus Cata; Didier Jutras-Aswad
Journal:  Subst Abuse       Date:  2015-05-21

Review 9.  Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature.

Authors:  Kiri L Wills; Linda A Parker
Journal:  Front Pharmacol       Date:  2016-06-28       Impact factor: 5.810
  9 in total

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