AIM: To present a case of combined small bowel and reduced auxiliary liver transplantation. METHODS: A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver function and to protect the intestinal allograft from rejection. His own liver was not removed. RESULTS: Without donor pretreatment and by conventional immunosuppresive therapy following transplantation, the patient experienced had only one episode of mild intestinal rejection, which was easily reversed by treatment with Methylprednisolone. No liver rejection occurred. Unfortunately, the patient died of heart and lung failure 30d after transplantation, despite successful graft replacement. Histopathologic examination of specimens after death demonstrated normal structure in both intestinal and liver grafts. CONCLUSION: The auxiliary liver graft might play a role in preventing intestinal allograft rejection. However, the observation period in this case is short. Further study is needed to determine the risks, effect on the protecting the small-bowel from rejection, and feasibility of general application of this procedure.
AIM: To present a case of combined small bowel and reduced auxiliary liver transplantation. METHODS: A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver function and to protect the intestinal allograft from rejection. His own liver was not removed. RESULTS: Without donor pretreatment and by conventional immunosuppresive therapy following transplantation, the patient experienced had only one episode of mild intestinal rejection, which was easily reversed by treatment with Methylprednisolone. No liver rejection occurred. Unfortunately, the patient died of heart and lung failure 30d after transplantation, despite successful graft replacement. Histopathologic examination of specimens after death demonstrated normal structure in both intestinal and liver grafts. CONCLUSION: The auxiliary liver graft might play a role in preventing intestinal allograft rejection. However, the observation period in this case is short. Further study is needed to determine the risks, effect on the protecting the small-bowel from rejection, and feasibility of general application of this procedure.
Authors: A G Tzakis; T Kato; S Nishida; N Mittal; G Neff; J Nery; C O'Brien; P Ruiz; D Levi; A Pinna Journal: Transplant Proc Date: 2001 Feb-Mar Impact factor: 1.066
Authors: J de Ville de Goyet; A Mitchell; A D Mayer; S V Beath; P J McKiernan; D A Kelly; D Mirza; J A Buckles Journal: Transplantation Date: 2000-02-27 Impact factor: 4.939
Authors: S Todo; A G Tzakis; K Abu-Elmagd; J Reyes; K Nakamura; A Casavilla; R Selby; B M Nour; H Wright; J J Fung Journal: Ann Surg Date: 1992-09 Impact factor: 12.969
Authors: K Abu-Elmagd; S Todo; A Tzakis; H Furukawa; B Nour; J Reyes; K Nakamura; C Scotti-Foglieni; H el-Hammadi; Z Kadry Journal: Transplant Proc Date: 1994-06 Impact factor: 1.066
Authors: Daniel Azoulay; Cyrille Feray; Chetana Lim; Chady Salloum; Maria Conticchio; Daniel Cherqui; Antonio Sa Cunha; René Adam; Eric Vibert; Didier Samuel; Marc Antoine Allard; Nicolas Golse Journal: JHEP Rep Date: 2022-02-12