| Literature DB >> 12378556 |
Takehito Yamamoto1, Makiko Kusama, Kumi Matsuno, Erika Sugiyama, Yasuhiko Yamada, Tatsuji Iga.
Abstract
Buformin is a widely used as an antidiabetic agent but its renal excretion is still controversial. A new HPLC method with ultraviolet (UV) detection for the determination of buformin in plasma and urine has been developed. After protein precipitation or dilution, buformin and internal standard phenformin were resolved on an octadecyl silica column and detected by UV detection at 233 nm. Intra- and inter-day coefficients of variation were <9%. The limit of quantification was around 0.05 micro g/ml for plasma and 2.5 micro g/ml for urine. Copyright 2002 John Wiley & Sons, Ltd.Entities:
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Year: 2002 PMID： 12378556 DOI： 10.1002/bmc.182
Source DB: PubMed Journal: Biomed Chromatogr ISSN： 0269-3879 Impact factor: 1.902