Literature DB >> 12377584

Strategic emphases for tropical diseases research: a TDR perspective.

Jan H F Remme1, Erik Blas, Lester Chitsulo, Philippe M P Desjeux, Howard D Engers, Thomas P Kanyok, Jane F Kengeya Kayondo, Deborah W Kioy, Vasanthapuram Kumaraswami, Janis K Lazdins, Paul P Nunn, Ayoade Oduola, Robert G Ridley, Yeya T Toure, Fabio Zicker, Carlos M Morel.   

Abstract

Setting priorities for health research is a difficult task, especially for the neglected diseases of the poor. A new approach to priority setting for tropical diseases research has been adopted by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (known as the TDR). Priorities are defined on the basis of a comprehensive analysis of research needs and research opportunities for each of the ten major tropical diseases in the TDR portfolio. The resulting strategic emphases matrix reflects the priorities for tropical diseases research from the perspective of the TDR. Its purpose is not to impose global research priorities, but we believe the results could be useful to other organizations.

Mesh:

Year:  2002        PMID: 12377584     DOI: 10.1016/s1471-4922(02)02387-5

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN: 1471-4922


  36 in total

1.  Neglected diseases: under-funded research and inadequate health interventions. Can we change this reality?

Authors:  Carlos M Morel
Journal:  EMBO Rep       Date:  2003-06       Impact factor: 8.807

2.  Representation of authors and editors from poor countries: observed publication bias may reflect who is funding research.

Authors:  Ranjit Manchanda; Rajesh Varma
Journal:  BMJ       Date:  2004-07-10

3.  Community-directed interventions for priority health problems in Africa: results of a multicountry study.

Authors: 
Journal:  Bull World Health Organ       Date:  2009-12-01       Impact factor: 9.408

4.  An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni-hookworm coinfection.

Authors:  Giovanna Raso; Penelope Vounatsou; Burton H Singer; Eliézer K N'Goran; Marcel Tanner; Jürg Utzinger
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-21       Impact factor: 11.205

5.  Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China.

Authors:  Song Liang; Edmund Y W Seto; Justin V Remais; Bo Zhong; Changhong Yang; Alan Hubbard; George M Davis; Xueguang Gu; Dongchuan Qiu; Robert C Spear
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-16       Impact factor: 11.205

Review 6.  Target assessment for antiparasitic drug discovery.

Authors:  Julie A Frearson; Paul G Wyatt; Ian H Gilbert; Alan H Fairlamb
Journal:  Trends Parasitol       Date:  2007-10-24

7.  Female-specific flightless phenotype for mosquito control.

Authors:  Guoliang Fu; Rosemary S Lees; Derric Nimmo; Diane Aw; Li Jin; Pam Gray; Thomas U Berendonk; Helen White-Cooper; Sarah Scaife; Hoang Kim Phuc; Osvaldo Marinotti; Nijole Jasinskiene; Anthony A James; Luke Alphey
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-22       Impact factor: 11.205

8.  In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination.

Authors:  Virginia L Tchakouté; Simon P Graham; Siv Aina Jensen; Benjamin L Makepeace; Charles K Nfon; Leo M Njongmeta; Sara Lustigman; Peter A Enyong; Vincent N Tanya; Albert E Bianco; Alexander J Trees
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-03       Impact factor: 11.205

9.  A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

Authors:  Elizabeth R Sharlow; Todd A Lyda; Heidi C Dodson; Gabriela Mustata; Meredith T Morris; Stephanie S Leimgruber; Kuo-Hsiung Lee; Yoshiki Kashiwada; David Close; John S Lazo; James C Morris
Journal:  PLoS Negl Trop Dis       Date:  2010-04-13

10.  A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

Authors:  Jacob D Durrant; Rommie E Amaro; Lei Xie; Michael D Urbaniak; Michael A J Ferguson; Antti Haapalainen; Zhijun Chen; Anne Marie Di Guilmi; Frank Wunder; Philip E Bourne; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2010-01-22       Impact factor: 4.475

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