| Literature DB >> 12376002 |
Claude Agami1, Luc Dechoux, Cécilia Ménard, Séverine Hebbe.
Abstract
The synthesis of enantiopure cis- and trans-2,3-disubstituted piperidines 4 is described. The key step of the synthesis involves the stereoselective reduction of chiral nonracemic lactams 2 by using BH3.Me2S. A rationalization of the stereoselectivity is presented.Entities:
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Year: 2002 PMID： 12376002 DOI： 10.1021/jo025955+
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354