| Literature DB >> 12375933 |
Barry M Trost1, John D Chisholm.
Abstract
[reaction: see text] An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol % [RuCl(2)(p-cymene)](2) in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.Entities:
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Year: 2002 PMID： 12375933 DOI： 10.1021/ol026726c
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005