Literature DB >> 12375891

A novel three-component reaction for the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinolines via 1,4-dipolar cycloaddition.

Vijay Nair1, A R Sreekanth, N Abhilash, Mohan M Bhadbhade, Rajesh C Gonnade.   

Abstract

[reaction: see text] The 1,4-dipole derived from isoquinoline and DMAD has been shown to react readily with N-tosylimines resulting in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives.

Entities:  

Year:  2002        PMID： 12375891     DOI： 10.1021/ol0264004

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Dipolar cycloaddition strategy for three-component synthesis of chromeno[3',4':3,4]pyrido[2,1-a]isoquinoline derivatives.

Authors:  Abdolali Alizadeh; Parinaz Jamal; Atefeh Roosta; Reza Rezaiyehraad; Tian-Fu Liu; Mojtaba Khanpour
Journal:  Mol Divers       Date:  2020-02-01       Impact factor: 2.943

2.  Dearomatization of electron poor six-membered N-heterocycles through [3 + 2] annulation with aminocyclopropanes.

Authors:  Johannes Preindl; Shyamal Chakrabarty; Jérôme Waser
Journal:  Chem Sci       Date:  2017-08-25       Impact factor: 9.825

3.  Cycloaddition of Huisgen 1,4-dipoles: synthesis and rapid epimerization of functionalized spiropyrido[2,1-b][1,3]oxazine-pyrroles and related products.

Authors:  Andrew R Galeev; Anna A Moroz; Maksim V Dmitriev; Andrey N Maslivets
Journal:  RSC Adv       Date:  2021-12-22       Impact factor: 3.361
  3 in total

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