BACKGROUND: Infections with simian foamy virus (SFV) are widely prevalent in nonhuman primates. SFV infection was confirmed in a worker, occupationally exposed to nonhuman primates, who donated blood after the retrospectively documented date of infection. Human-to-human transmission of SFV through transfusion and its pathogenicity have not been studied. STUDY DESIGN AND METHODS: Recipients of blood from this donor were identified and blood samples from such recipients were tested for SFV infection by Western blot and PCR assay. RESULTS: One recipient of RBCs and another recipient of FFP had died; retroviral infections were not implicated. One platelet recipient could not be tested. Recipients of RBCs (two), a WBC-reduced RBC unit (one), and a platelet unit (one) tested SFV-negative 19 months to 7 years after transfusion. Tested recipients had transfusions 3 to 35 days after blood donation. Samples of one lot of albumin and three lots of plasma protein fraction (manufactured from recovered plasma from two donations) tested negative both for antibodies and for viral RNA. CONCLUSION: SFV transmission through transfusion was not identified among four recipients of cellular blood components from one SFV-infected donor. Derivatives containing plasma from that donor tested negative for SFV.
BACKGROUND: Infections with simian foamy virus (SFV) are widely prevalent in nonhuman primates. SFV infection was confirmed in a worker, occupationally exposed to nonhuman primates, who donated blood after the retrospectively documented date of infection. Human-to-human transmission of SFV through transfusion and its pathogenicity have not been studied. STUDY DESIGN AND METHODS: Recipients of blood from this donor were identified and blood samples from such recipients were tested for SFV infection by Western blot and PCR assay. RESULTS: One recipient of RBCs and another recipient of FFP had died; retroviral infections were not implicated. One platelet recipient could not be tested. Recipients of RBCs (two), a WBC-reduced RBC unit (one), and a platelet unit (one) tested SFV-negative 19 months to 7 years after transfusion. Tested recipients had transfusions 3 to 35 days after blood donation. Samples of one lot of albumin and three lots of plasma protein fraction (manufactured from recovered plasma from two donations) tested negative both for antibodies and for viral RNA. CONCLUSION:SFV transmission through transfusion was not identified among four recipients of cellular blood components from one SFV-infecteddonor. Derivatives containing plasma from that donor tested negative for SFV.
Authors: James E Cummins; Roumiana S Boneva; William M Switzer; Logan L Christensen; Paul Sandstrom; Walid Heneine; Louisa E Chapman; Charlene S Dezzutti Journal: J Virol Date: 2005-10 Impact factor: 5.103
Authors: Lisa Jones-Engel; Katherine A Steinkraus; Shannon M Murray; Gregory A Engel; Richard Grant; Nantiya Aggimarangsee; Benjamin P Y-H Lee; Cynthia May; Michael A Schillaci; Chaleamchat Somgird; Tulyawat Sutthipat; Lucia Vojtech; JianYuan Zhao; Maxine L Linial Journal: J Virol Date: 2007-05-02 Impact factor: 5.103
Authors: William M Switzer; Vinod Bhullar; Vedapuri Shanmugam; Mian-Er Cong; Bharat Parekh; Nicholas W Lerche; JoAnn L Yee; John J Ely; Roumiana Boneva; Louisa E Chapman; Thomas M Folks; Walid Heneine Journal: J Virol Date: 2004-03 Impact factor: 5.103
Authors: Lisa Jones-Engel; Gregory A Engel; Michael A Schillaci; Aida Rompis; Artha Putra; Komang Gde Suaryana; Agustin Fuentes; Brigitte Beer; Sarah Hicks; Robert White; Brenda Wilson; Jonathan S Allan Journal: Emerg Infect Dis Date: 2005-07 Impact factor: 6.883
Authors: Sara Calattini; Fanélie Wanert; Bernard Thierry; Christine Schmitt; Sylviane Bassot; Ali Saib; Nicolas Herrenschmidt; Antoine Gessain Journal: Retrovirology Date: 2006-04-11 Impact factor: 4.602
Authors: Weimin Liu; Michael Worobey; Yingying Li; Brandon F Keele; Frederic Bibollet-Ruche; Yuanyuan Guo; Paul A Goepfert; Mario L Santiago; Jean-Bosco N Ndjango; Cecile Neel; Stephen L Clifford; Crickette Sanz; Shadrack Kamenya; Michael L Wilson; Anne E Pusey; Nicole Gross-Camp; Christophe Boesch; Vince Smith; Koichiro Zamma; Michael A Huffman; John C Mitani; David P Watts; Martine Peeters; George M Shaw; William M Switzer; Paul M Sharp; Beatrice H Hahn Journal: PLoS Pathog Date: 2008-07-04 Impact factor: 6.823