Literature DB >> 12374386

New anti-MRSA and anti-VRE carbapenems; synthesis and structure-activity relationships of 1beta-methyl-2-(thiazol-2-ylthio)carbapenems.

Makoto Sunagawa1, Masanori Itoh, Katsumi Kubota, Akira Sasaki, Yutaka Ueda, Peter Angehrn, Anne Bourson, Erwin Goetschi, Paul Hebeisen, Rudolf L Then.   

Abstract

Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant Streptococcus pneumoniae, a series of 1beta-methylcarbapenems with thiazol-2-ylthio groups at the C-2 position have been synthesized. Structure-activity relationships were investigated which led to SM-197436 (27), SM-232721 (44) and SM-232724 (41), being selected for further evaluation.

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Year:  2002        PMID： 12374386     DOI： 10.7164/antibiotics.55.722

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem.

Authors:  Yutaka Ueda; Katsunori Kanazawa; Ken Eguchi; Koji Takemoto; Yoshiro Eriguchi; Makoto Sunagawa
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

2.  Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals.

Authors:  Koichi Fujimoto; Koji Takemoto; Kazuo Hatano; Toru Nakai; Shigeyuki Terashita; Masahiro Matsumoto; Yoshiro Eriguchi; Ken Eguchi; Takeshi Shimizudani; Kimihiko Sato; Katsunori Kanazawa; Makoto Sunagawa; Yutaka Ueda
Journal:  Antimicrob Agents Chemother       Date:  2012-11-12       Impact factor: 5.191

3.  In vitro and in vivo activities of novel 2-(thiazol-2-ylthio)-1beta-methylcarbapenems with potent activities against multiresistant gram-positive bacteria.

Authors:  Yutaka Ueda; Makoto Sunagawa
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

4.  Pharmacodynamics of SMP-601 (PTZ601) against vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in neutropenic murine thigh infection models.

Authors:  Ken Eguchi; Katsunori Kanazawa; Yoshiro Eriguchi; Yutaka Ueda
Journal:  Antimicrob Agents Chemother       Date:  2009-06-01       Impact factor: 5.191

Review 5.  The Continuing Threat of Methicillin-Resistant Staphylococcus aureus.

Authors:  Márió Gajdács
Journal:  Antibiotics (Basel)       Date:  2019-05-02
  5 in total

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