| Literature DB >> 12374238 |
T Ljung1, M Staun, O Grove, O Fausa, M H Vatn, P M Hellström.
Abstract
Eight patients with pyoderma gangrenosum associated with Crohn disease were treated with infliximab. All had active mucosal inflammation indicated by endoscopic examination. Within 1-4 months, infliximab treatment resulted in complete healing of the pyoderma gangrenosum in 3 cases (1 parastomal, 2 lower limb), partial healing in 3 (2 parastomal, 1 lower limb) and temporary improvement in 2. Adverse effects such as skin rash, pneumonia and diarrhoea were seen in three patients. Our results imply that infliximab has a therapeutic potential on skin manifestations associated with inflammatory bowel disease, even though successful treatment may require repeat courses of infliximab infusions.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12374238 DOI： 10.1080/003655202320378338
Source DB: PubMed Journal: Scand J Gastroenterol ISSN： 0036-5521 Impact factor: 2.423