| Literature DB >> 12372534 |
Vinod R Hegde1, T-M Chan, Haiyan Pu, Vincent P Gullo, Mahesh G Patel, Pradip Das, Nicole Wagner, P S Parameswaran, C G Naik.
Abstract
The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K(i)) of 30 and 5microM, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50microM, suggesting their selectivity for the CCR5 receptor.Entities:
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Year: 2002 PMID： 12372534 DOI： 10.1016/s0960-894x(02)00599-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823