Literature DB >> 12372514

Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds.

Yousef Al-Abed1, Larisa Dubrovsky, Bela Ruzsicska, Mohindra Seepersaud, Michael Bukrinsky.   

Abstract

Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal.

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Year:  2002        PMID： 12372514     DOI： 10.1016/s0960-894x(02)00642-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein.

Authors:  Omar Haffar; Larisa Dubrovsky; Richard Lowe; Reem Berro; Fatah Kashanchi; Jeffrey Godden; Christophe Vanpouille; Jürgen Bajorath; Michael Bukrinsky
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

Review 2.  Strategies to inhibit viral protein nuclear import: HIV-1 as a target.

Authors:  Aviad Levin; Abraham Loyter; Michael Bukrinsky
Journal:  Biochim Biophys Acta       Date:  2010-08-16

Review 3.  Pharmacological inhibition of feline immunodeficiency virus (FIV).

Authors:  Hakimeh Mohammadi; Dorothee Bienzle
Journal:  Viruses       Date:  2012-04-27       Impact factor: 5.048

4.  Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives.

Authors:  Ayşegül GÜmÜŞ; Veysi OkumuŞ; Selçuk GÜmÜŞ
Journal:  Turk J Chem       Date:  2020-08-18       Impact factor: 1.239

5.  SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.

Authors:  Ru Bai; Xing-Jie Zhang; Yan-Li Li; Jing-Ping Liu; Hong-Bin Zhang; Wei-Lie Xiao; Jian-Xin Pu; Han-Dong Sun; Yong-Tang Zheng; Li-Xin Liu
Journal:  BMC Microbiol       Date:  2015-12-02       Impact factor: 3.605
  5 in total

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