| Literature DB >> 12372511 |
Hing L Sham1, Chen Zhao, Leping Li, David A Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck.
Abstract
The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1' positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12372511 DOI： 10.1016/s0960-894x(02)00643-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823