Literature DB >> 12372502

Novel nucleotide phosphonate analogues with potent antitumor activity.

Monica Bubenik1, Rabindra Rej, Nghe Nguyen-Ba, Giorgio Attardo, France Ouellet, Laval Chan.   

Abstract

We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC(50) values in the microM range. The synthesis as well as structure-activity relationship are described.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12372502     DOI: 10.1016/s0960-894x(02)00679-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis of Methylenecyclopropane Analogues of Antiviral Nucleoside Phosphonates.

Authors:  Zhaohua Yan; Shaoman Zhou; Earl R Kern; Jiri Zemlicka
Journal:  Tetrahedron       Date:  2006-03-13       Impact factor: 2.457

2.  Novel isoxazolidine analogues of homonucleosides and homonucleotides.

Authors:  Dorota G Piotrowska; Jan Balzarini; Graciela Andrei; Dominique Schols; Robert Snoeck; Andrzej E Wróblewski; Joanna Gotkowska
Journal:  Tetrahedron       Date:  2016-11-02       Impact factor: 2.457

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.