| Literature DB >> 12372498 |
Gulnur Arabaci1, Tian Yi, Hua Fu, Mary E Porter, Kirk D Beebe, Dehua Pei.
Abstract
A series of alpha-haloacetophenone derivatives was tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. The results show that the bromides are much more potent than the corresponding chlorides, whereas the phenyl ring is remarkably tolerant to modifications. Derivatization of the phenyl ring with a tripeptide Gly-Glu-Glu resulted in a potent, selective inhibitor against PTP1B.Entities:
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Year: 2002 PMID： 12372498 DOI： 10.1016/s0960-894x(02)00681-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823