Literature DB >> 12372494

Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B.

Osamu Yoshida1, Tatsuro Yasukata, Yukihito Sumino, Tadashi Munekage, Yukitoshi Narukawa, Yasuhiro Nishitani.   

Abstract

A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified derivatives having both hydrophobic and hydrophilic substituents exhibited potent antibacterial activity against MRSA and VRE along with considerable water-solubility.

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Year:  2002        PMID： 12372494     DOI： 10.1016/s0960-894x(02)00664-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives.

Authors:  Zhi-Chen Wu; Dale L Boger
Journal:  Tetrahedron       Date:  2019-02-04       Impact factor: 2.457

2.  Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.

Authors:  Venkateswarlu Yarlagadda; Mohini M Konai; Goutham B Manjunath; Chandradhish Ghosh; Jayanta Haldar
Journal:  J Antibiot (Tokyo)       Date:  2014-10-29       Impact factor: 2.649

3.  Polymerizable vancomycin derivatives for bactericidal biomaterial surface modification: structure-function evaluation.

Authors:  McKinley C Lawson; Richard Shoemaker; Kevin B Hoth; Christopher N Bowman; Kristi S Anseth
Journal:  Biomacromolecules       Date:  2009-08-10       Impact factor: 6.988
  3 in total

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