Reaction time slowing in adults with HIV: results of a meta-analysis using brinley plots.

A meta-analysis in the form of Brinley plots was conducted on the mean reaction times of HIV+ and HIV- groups. HIV+ reaction times were regressed on HIV- reaction times across 122 task conditions from 29 studies, producing a highly linear function (r(2) = .94), with a slope b = 1.039, which was not significantly different than b = 1.00. Asymptomatic and symptomatic HIV+ reaction times were also separately regressed on HIV- reaction times across 67 task conditions from 13 studies. Both functions were highly linear (r(2) = .97 and.90 respectively), with slopes of 1.034 and 1.117 respectively. Only the slope for symptomatic HIV+ groups was significantly larger than b = 1.00, suggesting a modest generalized slowing of cognition in these adults.