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Literature DB >> 12372295

Identification of TOR signaling complexes: more TORC for the cell growth engine.

Abstract

The Target of Rapamycin (TOR) proteins function in signaling pathways that promote protein synthesis and cell growth. In yeast, TOR signaling is regulated by nutrient availability, whereas in metazoan cells TOR activities may be controlled by both nutrients and growth factors. The recent identification of novel TOR-interacting proteins has provided crucial insights into TOR regulation and function.

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Year: 2002 PMID： 12372295 DOI： 10.1016/s0092-8674(02)01009-7

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

29 in total

1. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

Authors: Chi Kwan Tsang; Paula G Bertram; Wandong Ai; Ryan Drenan; X F Steven Zheng
Journal: EMBO J Date: 2003-11-17 Impact factor: 11.598

2. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.

Authors: Mario Pende; Sung Hee Um; Virginie Mieulet; Melanie Sticker; Valerie L Goss; Jurgen Mestan; Matthias Mueller; Stefano Fumagalli; Sara C Kozma; George Thomas
Journal: Mol Cell Biol Date: 2004-04 Impact factor: 4.272

3. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.

Authors: Magdy M Mahfouz; Sunghan Kim; Ashton J Delauney; Desh Pal S Verma
Journal: Plant Cell Date: 2005-12-23 Impact factor: 11.277

4. Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma.

Authors: Heather Francois-Vaughan; Adeola O Adebayo; Kate E Brilliant; Nicola M A Parry; Philip A Gruppuso; Jennifer A Sanders
Journal: Carcinogenesis Date: 2016-02-10 Impact factor: 4.944

5. The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Authors: Maria Fadri; Alexes Daquinag; Shimei Wang; Tao Xue; Jeannette Kunz
Journal: Mol Biol Cell Date: 2005-02-02 Impact factor: 4.138

6. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.

Authors: Yann-Gaël Gangloff; Matthias Mueller; Stephen G Dann; Petr Svoboda; Melanie Sticker; Jean-Francois Spetz; Sung Hee Um; Eric J Brown; Silvia Cereghini; George Thomas; Sara C Kozma
Journal: Mol Cell Biol Date: 2004-11 Impact factor: 4.272

Identification of TOR signaling complexes: more TORC for the cell growth engine.

1. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR.

2. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.

3. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.

4. Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma.

5. The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

6. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.

7. Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

8. Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.

9. Role of the steroid receptor coactivator SRC-3 in cell growth.

Review 10. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment.