Literature DB >> 12370103

Insights into obesity and insulin resistance from the study of extreme human phenotypes.

Stephen O'Rahilly1.   

Abstract

The detailed study of rare, extreme human phenotypes has a long and distinguished history in endocrinology. Such individuals have often acted as 'experiments of nature' providing important novel information regarding endocrine physiology and mechanistic insights relevant to the study of more common endocrine disorders. This review presents a personal experience of the study of two such extreme phenotypes, obesity and severe insulin resistance.

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Year:  2002        PMID： 12370103     DOI： 10.1530/eje.0.1470435

Source DB:  PubMed          Journal:  Eur J Endocrinol        ISSN： 0804-4643            Impact factor:   6.664


  5 in total

1.  Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction.

Authors:  Paul M Ridker; Nancy R Cook; Suzanne Cheng; Henry A Erlich; Klaus Lindpaintner; Jorge Plutzky; Robert Y L Zee
Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-03-27       Impact factor: 8.311

Review 2.  Human nutrition and food research: opportunities and challenges in the post-genomic era.

Authors:  Susan J Fairweather-Tait
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-10-29       Impact factor: 6.237

3.  Resistin induces rat insulinoma cell RINm5F apoptosis.

Authors:  Chun-lin Gao; De-yu Zhao; Jie Qiu; Chun-mei Zhang; Chen-bo Ji; Xiao-hui Chen; Feng Liu; Xi-rong Guo
Journal:  Mol Biol Rep       Date:  2008-10-07       Impact factor: 2.316

4.  Defining Extreme Phenotypes of OSA Across International Sleep Centers.

Authors:  Fabiola G Rizzatti; Diego R Mazzotti; Jesse Mindel; Greg Maislin; Brendan T Keenan; Lia Bittencourt; Ning-Hung Chen; Peter A Cistulli; Nigel McArdle; Frances M Pack; Bhajan Singh; Kate Sutherland; Bryndis Benediktsdottir; Ingo Fietze; Thorarinn Gislason; Diane C Lim; Thomas Penzel; Bernd Sanner; Fang Han; Qing Yun Li; Richard Schwab; Sergio Tufik; Allan I Pack; Ulysses J Magalang
Journal:  Chest       Date:  2020-04-15       Impact factor: 10.262

5.  Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity.

Authors:  Leon G Straub; Vissarion Efthymiou; Gerald Grandl; Miroslav Balaz; Tenagne Delessa Challa; Luca Truscello; Carla Horvath; Caroline Moser; Yael Rachamin; Myrtha Arnold; Wenfei Sun; Salvatore Modica; Christian Wolfrum
Journal:  Diabetologia       Date:  2019-07-15       Impact factor: 10.122
  5 in total

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