Literature DB >> 12370074

Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.

J Yang1, L K Klaidman, J D Adams.   

Abstract

Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

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Year:  2002        PMID： 12370074     DOI： 10.2174/1389557024605483

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  9 in total

Review 1.  Nicotinamide: a jack of all trades (but master of none?).

Authors:  Csaba Szabó
Journal:  Intensive Care Med       Date:  2003-04-24       Impact factor: 17.440

Review 2.  Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies.

Authors:  Cole Vonder Haar; Todd C Peterson; Kris M Martens; Michael R Hoane
Journal:  Brain Res       Date:  2015-12-23       Impact factor: 3.252

3.  Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury.

Authors:  Cole Vonder Haar; Gail D Anderson; Michael R Hoane
Journal:  Behav Brain Res       Date:  2011-06-17       Impact factor: 3.332

4.  Sustained delivery of nicotinamide limits cortical injury and improves functional recovery following traumatic brain injury.

Authors:  Andrea M Goffus; Gail D Anderson; Michael Hoane
Journal:  Oxid Med Cell Longev       Date:  2010 Mar-Apr       Impact factor: 6.543

5.  Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition.

Authors:  Lisa M Giammona; Swapna Panuganti; Jan M Kemper; Pani A Apostolidis; Stephan Lindsey; Eleftherios T Papoutsakis; William M Miller
Journal:  Exp Hematol       Date:  2009-08-26       Impact factor: 3.084

6.  Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat.

Authors:  M R Hoane; J L Pierce; M A Holland; G D Anderson
Journal:  Neuroscience       Date:  2008-05-02       Impact factor: 3.590

7.  Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia.

Authors:  Pavan K Shetty; Francesca Galeffi; Dennis A Turner
Journal:  Neurobiol Dis       Date:  2013-10-31       Impact factor: 5.996

8.  Variation in chronic nicotinamide treatment after traumatic brain injury can alter components of functional recovery independent of histological damage.

Authors:  Michael R Hoane; Jeremy L Pierce; Nicholas A Kaufman; Jason E Beare
Journal:  Oxid Med Cell Longev       Date:  2008 Oct-Dec       Impact factor: 6.543

9.  The effect of nicotinamide on gene expression in a traumatic brain injury model.

Authors:  G D Anderson; T C Peterson; F M Farin; T K Bammler; R P Beyer; E D Kantor; M R Hoane
Journal:  Front Neurosci       Date:  2013-02-26       Impact factor: 4.677
  9 in total

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