Literature DB >> 12370064

cycloSal-pronucleotides design of chemical trojan horses.

Chris Meier1.   

Abstract

Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogues against different viral diseases. The basic idea is to achieve nucleotide delivery into cells bypassing limitations encountered during the intracellular formation of nucleotides. The cycloSal-concept is one of several pronucleotide systems reported so far. For some nucleoside analogues, the cycloSal-approach improved antiviral potency thus broadening the applicability of nucleosides. The initial design, chemistry, the proof-of-principle and different applications of the cycloSal-strategy will be discussed in this review.

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Year:  2002        PMID： 12370064     DOI： 10.2174/1389557023406205

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.

Authors:  Zbigniew P Kortylewicz; Yu Kimura; Kotaro Inoue; Elizabeth Mack; Janina Baranowska-Kortylewicz
Journal:  J Med Chem       Date:  2012-03-08       Impact factor: 7.446

Review 2.  Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions.

Authors:  Emma S Rudge; Alex H Y Chan; Finian J Leeper
Journal:  RSC Med Chem       Date:  2022-03-01

Review 3.  Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues.

Authors:  Larryn W Peterson; Charles E McKenna
Journal:  Expert Opin Drug Deliv       Date:  2009-04       Impact factor: 6.648

4.  Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation.

Authors:  Shui Li; Yan Jia; Blake Jacobson; Joel McCauley; Robert Kratzke; Peter B Bitterman; Carston R Wagner
Journal:  Mol Pharm       Date:  2013-02-04       Impact factor: 4.939

5.  Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cyclosaligenyl phosphitylating reagents.

Authors:  Yousef Ahmadibeni; Rakesh K Tiwari; Gongqin Sun; Keykavous Parang
Journal:  Org Lett       Date:  2009-05-21       Impact factor: 6.005

6.  Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.

Authors:  Yousef Ahmadibeni; Rakesh Tiwari; Chelsie Swepson; Jui Pandhare; Chandravanu Dash; Gustavo F Doncel; Keykavous Parang
Journal:  Tetrahedron Lett       Date:  2010-12-15       Impact factor: 2.415

7.  Antiviral nucleoside analogs.

Authors:  Vladimir E Kataev; Bulat F Garifullin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-14       Impact factor: 1.277

8.  The First 5'-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation.

Authors:  Dmitry A Tatarinov; Bulat F Garifullin; Mayya G Belenok; Olga V Andreeva; Irina Yu Strobykina; Anna V Shepelina; Vladimir V Zarubaev; Alexander V Slita; Alexandrina S Volobueva; Liliya F Saifina; Marina M Shulaeva; Vyacheslav E Semenov; Vladimir E Kataev
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927

Review 9.  Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.

Authors:  Nikolaos Tsesmetzis; Cynthia B J Paulin; Sean G Rudd; Nikolas Herold
Journal:  Cancers (Basel)       Date:  2018-07-23       Impact factor: 6.639

Review 10.  Synthetic Strategies for Dinucleotides Synthesis.

Authors:  Lucie Appy; Crystalle Chardet; Suzanne Peyrottes; Béatrice Roy
Journal:  Molecules       Date:  2019-11-27       Impact factor: 4.411
  10 in total

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