Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Design, synthesis, and application of peptide secondary structure mimetics.

Literature DB >> 12370046

Design, synthesis, and application of peptide secondary structure mimetics.

Abstract

The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.

Mesh：

Substances：
Peptides

Year: 2002 PMID： 12370046 DOI： 10.2174/1389557023405783

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

Keyword Cloud
Cited

9 in total

1. Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

Authors: Jaru Taechalertpaisarn; Rui-Liang Lyu; Maritess Arancillo; Chen-Ming Lin; Lisa M Perez; Thomas R Ioerger; Kevin Burgess
Journal: Org Biomol Chem Date: 2019-03-20 Impact factor: 3.876

2. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.

Authors: Landon R Whitby; Yoshio Ando; Vincent Setola; Peter K Vogt; Bryan L Roth; Dale L Boger
Journal: J Am Chem Soc Date: 2011-06-15 Impact factor: 15.419

3. Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.

Authors: Xuemei Chen; Ruud P M Dings; Irina Nesmelova; Stefan Debbert; Judith R Haseman; Jacques Maxwell; Thomas R Hoye; Kevin H Mayo
Journal: J Med Chem Date: 2006-12-28 Impact factor: 7.446

9. Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation.

Authors: Mythily Srinivasan; Corinne Blackburn; Debomoy K Lahiri
Journal: Drug Des Devel Ther Date: 2014-12-03 Impact factor: 4.162

9 in total

Design, synthesis, and application of peptide secondary structure mimetics.

1. Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

2. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.

3. Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins.

4. Beta-turn secondary structure and melanocortin ligands.

5. A multifaceted secondary structure mimic based on piperidine-piperidinones.

6. Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.

7. Comprehensive peptidomimetic libraries targeting protein-protein interactions.

8. Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.

9. Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation.