Literature DB >> 12370038

Vitronectin receptor alpha(V)beta(3) integrin antagonists: chemical and structural requirements for activity and selectivity.

Christophe Henry1, Nicolas Moitessier, Yves Chapleur.   

Abstract

Alpha(V)beta(3) integrin, a cell surface protein, has been targeted by a variety of natural and synthetic antagonists in the search for potential cancer and osteoporosis drug candidates. This review discusses chemical and structural requirements for activity and selectivity deduced from SAR studies and draws a tentative picture of the pharmacophore.

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Year:  2002        PMID： 12370038     DOI： 10.2174/1389557023405602

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  3 in total

1.  The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor.

Authors:  Nunzia Montuori; Katia Bifulco; Maria Vincenza Carriero; Claudio La Penna; Valeria Visconte; Daniela Alfano; Ada Pesapane; Francesca Wanda Rossi; Salvatore Salzano; Guido Rossi; Pia Ragno
Journal:  Cell Mol Life Sci       Date:  2010-10-24       Impact factor: 9.261

2.  Small molecule inhibitors of hantavirus infection.

Authors:  Pamela R Hall; Andrei Leitão; Chunyan Ye; Kathleen Kilpatrick; Brian Hjelle; Tudor I Oprea; Richard S Larson
Journal:  Bioorg Med Chem Lett       Date:  2010-09-19       Impact factor: 2.823

3.  Stroma targeting nuclear imaging and radiopharmaceuticals.

Authors:  Dinesh Shetty; Jae-Min Jeong; Hyunsuk Shim
Journal:  Int J Mol Imaging       Date:  2012-05-21
  3 in total

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