OBJECTIVE: The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. METHODS: We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. RESULTS: Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P < .001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P < .001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4% +/- 9.8%; C-scan, -7.4% +/- 8.0%; P < .001; mean difference for stroke volumes: B-scan, 3.0% +/- 19.1%; C-scan, -2.5% +/- 20.9%; P < .001). CONCLUSIONS: Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.
OBJECTIVE: The complex structural geometry of the right ventricle hinders accurate assessment of right ventricular volume and function on conventional two-dimensional echocardiography. We sought to evaluate the accuracy of real-time three-dimensional echocardiography for quantifying the volume of the right ventricle in an in vitro experimental study. METHODS: We developed 39 anatomically accurate latex phantoms of human and porcine right ventricles (range, 24-108 mL) for 39 static and 10 pulsatile models. Real-time three-dimensional scanning was performed with the models placed in a water bath and with a 3.5-MHz probe. In the dynamic models a pulsatile flow pump generated 2 different stroke volumes (29 and 64 mL/beat). Static chamber volumes and stroke volumes were verified by water displacement, which served as a reference standard. Three-dimensional echo right ventricle volumes were determined by tracing derived B- and C-scans, using the Simpson rule. RESULTS: Multiple regression analyses showed an excellent correlation between real-time three-dimensional echocardiographic determinations and the static volumes (B-scan, r = 0.99; C-scan, r = 0.98; P < .001), as well as stroke volumes in the dynamic model (B-scan, r = 0.90; C-scan, r = 0.86; P < .001). However, the C-scans tended to underestimate cavity and stroke volumes more than the B-scans (mean difference for static volume: B-scan, 1.4% +/- 9.8%; C-scan, -7.4% +/- 8.0%; P < .001; mean difference for stroke volumes: B-scan, 3.0% +/- 19.1%; C-scan, -2.5% +/- 20.9%; P < .001). CONCLUSIONS: Real-time three-dimensional echocardiography can accurately quantify right ventricle cavity volumes and stroke volumes without geometric assumptions.
Authors: Isaac R Whitman; Vickas V Patel; Elsayed Z Soliman; David A Bluemke; Amy Praestgaard; Aditya Jain; David Herrington; Joao A C Lima; Steven M Kawut Journal: J Am Coll Cardiol Date: 2013-09-28 Impact factor: 24.094