Retinol palmitate as a model substance to test antioxidant properties in vitro on the example of captopril.

In the test of accelerated ageing it has been shown that captopril inhibits autooxidation of retinol palmitate. The results of the test have confirmed that retinol palmitate can be used as a model substance to estimate the effectiveness of antioxidant properties of different agents. The study was performed for different temperatures and concentrations of captopril. In order to estimate the strength of the antioxidant effect of captopril its activity was compared with that of the well known antioxidant octyl gallate. The thermodynamic parameters and frequency index of the decomposition of retinol palmitate were determined.