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Literature DB >> 12367630

PTEN function in mammalian cell size regulation.

Stéphanie Backman¹, Vuk Stambolic, Tak Mak.

Abstract

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

Entities: Disease Gene Species

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Year: 2002 PMID： 12367630 DOI： 10.1016/s0959-4388(02)00354-9

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

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Cited

34 in total

1. Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.

Authors: Margaret Sperow; Raymond B Berry; Ildar T Bayazitov; Guo Zhu; Suzanne J Baker; Stanislav S Zakharenko
Journal: J Physiol Date: 2011-12-06 Impact factor: 5.182

2. Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Authors: Nick R Leslie; Deborah Bennett; Yvonne E Lindsay; Hazel Stewart; Alex Gray; C Peter Downes
Journal: EMBO J Date: 2003-10-15 Impact factor: 11.598

3. Muscle-specific Pten deletion protects against insulin resistance and diabetes.

Authors: Nadeeja Wijesekara; Daniel Konrad; Mohamed Eweida; Craig Jefferies; Nicole Liadis; Adria Giacca; Mike Crackower; Akira Suzuki; Tak W Mak; C Ronald Kahn; Amira Klip; Minna Woo
Journal: Mol Cell Biol Date: 2005-02 Impact factor: 4.272

4. Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors.

Authors: Edmond J Yunis; Joaquin Zúñiga; Prasad S Koka; Zaheed Husain; Viviana Romero; Joel N H Stern; Masha Fridkis-Hareli
Journal: J Stem Cells Date: 2006

5. The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.

Authors: Yosuke Ohtake; Dongsun Park; P M Abdul-Muneer; Hui Li; Bin Xu; Kartavya Sharma; George M Smith; Michael E Selzer; Shuxin Li
Journal: Biomaterials Date: 2014-03-12 Impact factor: 12.479

6. Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes.

Authors: Xinhe Wang; Dibyendu Bhattacharyya; Margaret B Dennewitz; Vladimir V Kalinichenko; Yan Zhou; Rita Lepe; Robert H Costa
Journal: Gene Expr Date: 2003

PTEN function in mammalian cell size regulation.

1. Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.

2. Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

3. Muscle-specific Pten deletion protects against insulin resistance and diabetes.

4. Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors.

5. The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.

6. Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes.

7. Lifelong accumulation of bone in mice lacking Pten in osteoblasts.

Review 8. Update on the management of familial central nervous system tumor syndromes.

9. Missense mutation in the PTEN promoter of a patient with hemifacial hyperplasia.

10. Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.