Robyn Guymer1. 1. Macular Research Unit, Centre for Eye Research Australia, 32 Gisborne Street, East Melbourne, VIC, 3002, Australia.
Abstract
AIM: To review the genetics of age-related macular degeneration (AMD). The pathogenesis of AMD, the leading cause of severe visual disability and blindness in our community, remains unknown. However, AMD is regarded as a genetic disease where family history of AMD is a significant risk factor for the disease. Understanding the genetic factors associated with AMD offers the greatest chance for understanding the underlying disease processes. METHODS: Through a review of the literature and the use of original research findings, the current knowledge of the genetics of AMD is explored. CONCLUSION: AMD is increasing in prevalence and remains a major challenge for eye heath providers. Finding the genes that are associated with AMD offers the greatest chance for the development of preventative strategies and treatments.
AIM: To review the genetics of age-related macular degeneration (AMD). The pathogenesis of AMD, the leading cause of severe visual disability and blindness in our community, remains unknown. However, AMD is regarded as a genetic disease where family history of AMD is a significant risk factor for the disease. Understanding the genetic factors associated with AMD offers the greatest chance for understanding the underlying disease processes. METHODS: Through a review of the literature and the use of original research findings, the current knowledge of the genetics of AMD is explored. CONCLUSION:AMD is increasing in prevalence and remains a major challenge for eye heath providers. Finding the genes that are associated with AMD offers the greatest chance for the development of preventative strategies and treatments.
Authors: Minh Thuan Nguyen Tran; Mohd Khairul Nizam Mohd Khalid; Alice Pébay; Anthony L Cook; Helena H Liang; Raymond C B Wong; Jamie E Craig; Guei-Sheung Liu; Sandy S Hung; Alex W Hewitt Journal: Mol Vis Date: 2019-03-16 Impact factor: 2.367
Authors: Nancy Gelvez; Paula Hurtado-Villa; Silvia Flórez; Anne Charlotte Brieke; Francisco Rodríguez; Ana María Bertolotto; Martha L Tamayo Journal: Biomedica Date: 2021-09-22 Impact factor: 0.935