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Literature DB >> 1236625

Variations in the level of a pregnancy-associated alpha-macroglobulin in patients with cancer.

Abstract

The concentration of a pregnancy-associated alpha-macroglobulin (PAM) was determined in the blood of patients with various cancers. PAM was detectable in subjects with all types of malignant disease studied, and the level of the serum protein correlated well with the course of the disease: the concentration increased before clinical recognition of metastases and decreased significantly on successful treatment. Periodic PAM determinations may allow detection of tumour recurrence while it is still at a treatable stage and could aid in the evaluation of therapy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1975 PMID： 1236625 PMCID： PMC475885 DOI： 10.1136/jcp.28.11.868

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

22 in total

1. Synthesis of a pregnancy-associated alpha-macroglobulin by human leucocytes.

Authors: W H Stimson; J C Blackstock
Journal: Experientia Date: 1975-03-15

2. Lack of steroid-binding by "pregnancy zone" protein.

Authors: B von Schoultz; T Stigbrand; H Carstensen; R Södergård; V Shanbhag
Journal: J Steroid Biochem Date: 1973-09 Impact factor: 4.292

3. Inhibition of PHA-induced lymphocyte stimulation by the pregnancy zone protein.

Authors: B Von Schoultz; T Stigbrand; A Tärnvik
Journal: FEBS Lett Date: 1973-12-15 Impact factor: 4.124

4. Detection of the "pregnancy zone" protein by means of an immunodiffusion method.

Authors: L Beckman; B von Schoultz; T Stigbrand
Journal: Acta Obstet Gynecol Scand Date: 1973 Impact factor: 3.636

5. Normal and increased alpha-fetoprotein in neoplastic and non-neoplastic liver disease.

Authors: E Ruoslahti; M Seppälä
Journal: Lancet Date: 1972-08-05 Impact factor: 79.321

6. Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.

Authors: G I Abelev
Journal: Cancer Res Date: 1968-07 Impact factor: 12.701

7. Proceedings: Carcinoembryonic antigen. Report of a screening study.

Authors: M E Costanza; S Das; L Nathanson; A Rule; R S Schwartz
Journal: Cancer Date: 1974-02 Impact factor: 6.860

8. Variations in the serum concentration of a human pregnancy-associated alpha-macroglobulin during pregnancy and after delivery.

Authors: W H Stimson
Journal: J Reprod Fertil Date: 1975-06

9. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors: C B Laurell
Journal: Anal Biochem Date: 1966-04 Impact factor: 3.365

Review 10. Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review.

Authors: D J Laurence; A M Neville
Journal: Br J Cancer Date: 1972-10 Impact factor: 7.640

8 in total

1. Cancer-associated proteins in effusion fluids.

Authors: S N Booth; G Lakin; P W Dykes; D Burnett; A R Bradwell
Journal: J Clin Pathol Date: 1977-06 Impact factor: 3.411

2. Studies on the immunosuppressive properties of a pregnancy-associated alpha-macroglobulin.

Authors: W H Stimson
Journal: Clin Exp Immunol Date: 1976-08 Impact factor: 4.330

3. The detection and measurement of oncodevelopmental proteins in gynecological malignant disease.

Authors: C Cerni; G Tatra
Journal: Arch Gynecol Date: 1982

4. A critical comparison of the value of pregnancy-associated alpha2-glycoprotein and carcinoembryonic antigen assays in patients with colorectal cancer.

Authors: C B Wood; C H Horne; C M Towler; R W Burt; J G Ratcliffe; L H Blumgart
Journal: J Clin Pathol Date: 1978-11 Impact factor: 3.411