Literature DB >> 12365824

Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke.

Kyra J Becker1.   

Abstract

An abundance of experimental data show that inflammation contributes to cerebral ischaemic injury and that attenuation of the inflammatory response can improve outcome. The two clinical trials of therapy aimed at limiting the inflammatory response in acute stroke that have been carried out to date, however, have not shown a benefit to such therapy. The potential reasons for the failure of these trials are discussed.

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Year:  2002        PMID: 12365824     DOI: 10.1185/030079902125000688

Source DB:  PubMed          Journal:  Curr Med Res Opin        ISSN: 0300-7995            Impact factor:   2.580


  58 in total

Review 1.  Leucocyte/endothelium interactions and microvessel permeability: coupled or uncoupled?

Authors:  Pingnian He
Journal:  Cardiovasc Res       Date:  2010-05-13       Impact factor: 10.787

Review 2.  The inflammatory response in stroke.

Authors:  Qing Wang; Xian Nan Tang; Midori A Yenari
Journal:  J Neuroimmunol       Date:  2006-12-26       Impact factor: 3.478

Review 3.  Inflammatory responses in brain ischemia.

Authors:  Masahito Kawabori; Midori A Yenari
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

Review 4.  Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.

Authors:  Chengrui An; Yejie Shi; Peiying Li; Xiaoming Hu; Yu Gan; Ruth A Stetler; Rehana K Leak; Yanqin Gao; Bao-Liang Sun; Ping Zheng; Jun Chen
Journal:  Prog Neurobiol       Date:  2013-12-26       Impact factor: 11.685

5.  Bone marrow chimeras in the study of experimental stroke.

Authors:  Xian Nan Tang; Zhen Zheng; Midori A Yenari
Journal:  Transl Stroke Res       Date:  2012-05-05       Impact factor: 6.829

6.  Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia.

Authors:  Jin Yu; Hong Zhu; Saeid Taheri; William Mondy; Leonardo Bonilha; Gayenell S Magwood; Daniel Lackland; Robert J Adams; Mark S Kindy
Journal:  J Neurosci       Date:  2019-10-14       Impact factor: 6.167

Review 7.  Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke.

Authors:  Sajad Sarvari; Faezeh Moakedi; Emily Hone; James W Simpkins; Xuefang Ren
Journal:  Metab Brain Dis       Date:  2020-04-15       Impact factor: 3.584

8.  ICAM-1null C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke.

Authors:  Gaby U Enzmann; Sofia Pavlidou; Markus Vaas; Jan Klohs; Britta Engelhardt
Journal:  Transl Stroke Res       Date:  2018-02-04       Impact factor: 6.829

9.  Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.

Authors:  Bridgette D Semple; Alpa Trivedi; Kayleen Gimlin; Linda J Noble-Haeusslein
Journal:  Neurobiol Dis       Date:  2014-12-09       Impact factor: 5.996

Review 10.  Monoclonal antibody as an emerging therapy for acute ischemic stroke.

Authors:  Demi Woods; Qian Jiang; Xiang-Ping Chu
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2020-08-25
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