Literature DB >> 12364789

Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.

Thomas E Wellems1.   

Abstract

Genetic and biochemical research is providing new information on the mechanism of chloroquine resistance. Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria.

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Year:  2002        PMID： 12364789     DOI： 10.1126/science.1078167

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.

Authors:  Godfrey Lisk; Margaret Pain; Ilya Y Gluzman; Shivkumar Kambhampati; Tetsuya Furuya; Xin-Zhuan Su; Michael P Fay; Daniel E Goldberg; Sanjay A Desai
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191

2.  In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum.

Authors:  Dieudonné Ndjonka; Bärbel Bergmann; Christian Agyare; Flávia M Zimbres; Kai Lüersen; Andreas Hensel; Carsten Wrenger; Eva Liebau
Journal:  Parasitol Res       Date:  2012-04-05       Impact factor: 2.289

Review 3.  Resisting resistance: gearing up for war.

Authors:  Aurijit Sarkar; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2019-08-07       Impact factor: 3.597

4.  In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10.

Authors:  Mohd Shukri Baba; Noraziah Mohamad Zin; Zainal Abidin Abu Hassan; Jalifah Latip; Florence Pethick; Iain S Hunter; RuAngelie Edrada-Ebel; Paul R Herron
Journal:  J Microbiol       Date:  2015-12-02       Impact factor: 3.422

5.  Molecular dynamics studies of a hexameric purine nucleoside phosphorylase.

Authors:  Fernando Berton Zanchi; Rafael Andrade Caceres; Rodrigo Guerino Stabeli; Walter Filgueira de Azevedo
Journal:  J Mol Model       Date:  2009-08-11       Impact factor: 1.810

6.  Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax.

Authors:  Pan-Pan Jiang; Russell B Corbett-Detig; Daniel L Hartl; Elena R Lozovsky
Journal:  J Mol Evol       Date:  2013-09-27       Impact factor: 2.395

7.  2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

Authors:  Kamaljit Singh; Hardeep Kaur; Kelly Chibale; Jan Balzarini; Susan Little; Prasad V Bharatam
Journal:  Eur J Med Chem       Date:  2012-03-13       Impact factor: 6.514

8.  Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates.

Authors:  Warangkhana Songsungthong; Pongpisid Koonyosying; Chairat Uthaipibull; Sumalee Kamchonwongpaisan
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

9.  Discovery of dual function acridones as a new antimalarial chemotype.

Authors:  Jane X Kelly; Martin J Smilkstein; Reto Brun; Sergio Wittlin; Roland A Cooper; Kristin D Lane; Aaron Janowsky; Robert A Johnson; Rozalia A Dodean; Rolf Winter; David J Hinrichs; Michael K Riscoe
Journal:  Nature       Date:  2009-04-08       Impact factor: 49.962

10.  Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum.

Authors:  Adina Heinberg; Edwin Siu; Chaya Stern; Elizabeth A Lawrence; Michael T Ferdig; Kirk W Deitsch; Laura A Kirkman
Journal:  Mol Microbiol       Date:  2013-04-24       Impact factor: 3.501
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