Literature DB >> 12361871

A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion.

Robert K Shepherd1, Jin Xu.   

Abstract

We have developed a novel scala tympani electrode array suitable for use in experimental animals. A unique feature of this array is its ability to chronically deliver pharmacological agents to the scala tympani. The design of the electrode array is described in detail. Experimental studies performed in guinea pigs confirm that this array can successfully deliver various drugs to the cochlea while chronically stimulating the auditory nerve.

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Year:  2002        PMID： 12361871     DOI： 10.1016/s0378-5955(02)00517-8

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  27 in total

1.  In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants.

Authors:  Ya Liu; Claude Jolly; Susanne Braun; Thomas Stark; Elias Scherer; Stefan K Plontke; Jan Kiefer
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-08-29       Impact factor: 2.503

2.  A fully implantable stimulator for use in small laboratory animals.

Authors:  Rodney E Millard; Robert K Shepherd
Journal:  J Neurosci Methods       Date:  2007-07-24       Impact factor: 2.390

3.  Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants.

Authors:  Thomas G Landry; James B Fallon; Andrew K Wise; Robert K Shepherd
Journal:  J Comp Neurol       Date:  2013-08-15       Impact factor: 3.215

Review 4.  [Intracochlear drug delivery in combination with cochlear implants : Current aspects].

Authors:  S K Plontke; G Götze; T Rahne; A Liebau
Journal:  HNO       Date:  2016-11       Impact factor: 1.284

Review 5.  Microsystems technologies for drug delivery to the inner ear.

Authors:  Erin E Leary Pararas; David A Borkholder; Jeffrey T Borenstein
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

Review 6.  Intracochlear drug delivery systems.

Authors:  Jeffrey T Borenstein
Journal:  Expert Opin Drug Deliv       Date:  2011-05-26       Impact factor: 6.648

7.  A fully implantable rodent neural stimulator.

Authors:  D W J Perry; D B Grayden; R K Shepherd; J B Fallon
Journal:  J Neural Eng       Date:  2012-01-17       Impact factor: 5.379

8.  Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons.

Authors:  Rachael T Richardson; Andrew K Wise; Brianna C Thompson; Brianna O Flynn; Patrick J Atkinson; Nicole J Fretwell; James B Fallon; Gordon G Wallace; Rob K Shepherd; Graeme M Clark; Stephen J O'Leary
Journal:  Biomaterials       Date:  2009-01-29       Impact factor: 12.479

9.  Bilateral cochlear implantation in the ferret: a novel animal model for behavioral studies.

Authors:  Douglas E H Hartley; Tara Vongpaisal; Jin Xu; Robert K Shepherd; Andrew J King; Amal Isaiah
Journal:  J Neurosci Methods       Date:  2010-05-31       Impact factor: 2.390

10.  Enhanced survival of spiral ganglion cells after cessation of treatment with brain-derived neurotrophic factor in deafened guinea pigs.

Authors:  Martijn J H Agterberg; Huib Versnel; Lotte M van Dijk; John C M J de Groot; Sjaak F L Klis
Journal:  J Assoc Res Otolaryngol       Date:  2009-04-14
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