| Literature DB >> 12361406 |
Petra Adam1, Duilio Arigoni, Adelbert Bacher, Wolfgang Eisenreich.
Abstract
Cut sprouts of Hypericum perforatum were proffered solutions containing [1-(13)C]glucose or [U-(13)C(6)]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.Entities:
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Year: 2002 PMID： 12361406 DOI： 10.1021/jm0209782
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446