| Literature DB >> 12360330 |
S A Afanas'ev1, I A Lukavskaya, M L Kandinskii, M A Medvedev.
Abstract
Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The preparation significantly increased all the parameters of postextrasystolic contraction. It was concluded that amiodarone potentiates the ability of sarcoplasmic reticulum to accumulate Ca2+ ions.Entities:
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Year: 2002 PMID： 12360330 DOI： 10.1023/a:1015832710818
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804