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Literature DB >> 12360190

The spindle checkpoint: structural insights into dynamic signalling.

Abstract

Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.

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Year: 2002 PMID： 12360190 DOI： 10.1038/nrm929

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

176 in total

1. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.

Authors: Gourish Mondal; Akihiro Ohashi; Lin Yang; Matthew Rowley; Fergus J Couch
Journal: Mol Cell Date: 2012-03-09 Impact factor: 17.970

2. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.

Authors: Susan L Kline-Smith; Alexey Khodjakov; Polla Hergert; Claire E Walczak
Journal: Mol Biol Cell Date: 2003-12-29 Impact factor: 4.138

The spindle checkpoint: structural insights into dynamic signalling.

1. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.

2. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.

3. Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.

Review 4. The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation.

Review 5. Kinetochore-microtubule interactions during cell division.

6. Kinetochore localization of spindle checkpoint proteins: who controls whom?

7. The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli.

8. Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC).

9. A novel function of Rab5 in mitosis.

10. The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.