BACKGROUND: Limited data are available on the effect of anemia on mortality in patients with acute myocardial infarction (MI). METHODS: We examined the association of anemia with mortality at 1 year among 30,341 patients hospitalized with acute MI in 1986 (prethrombolytic era, n = 15,584) and 1996 (thrombolytic era, n = 14,757). The records were obtained from the Myocardial Infarction Data Acquisition System, a database of all patients with MI admitted to nonfederal hospitals in New Jersey. RESULTS: Anemia was present in 996 patients (6.4%) in 1986 and 1510 patients (10.2%, P <.0001) in 1996. In both years, patients with anemia were older, more frequently female and nonwhite, and more likely to have left ventricular dysfunction, non-Q MI and coronary artery bypass graft. In addition, in 1996, patients with anemia were more likely to undergo percutaneous transluminal coronary angioplasty and less likely to have a history of MI. One-year mortality was lower overall in 1996 compared with 1986 (1996 23.6%, 95% CI 22.9-24.3 vs 1986 24.9%, 95% CI 24.2-25.6, P =.0001). In both years, patients with anemia had significantly higher unadjusted risk for 1-year mortality (RR = 1.40, P =.0001 in both years). However, after controlling for demographics, left ventricular dysfunction, arrhythmias, Q versus non-Q MI, comorbid conditions, and revascularization procedures in a multivariable regression model, 1-year mortality in the anemia group was similar to the nonanemia group in both years. CONCLUSION: In the Myocardial Infarction Data Acquisition System database, anemia appears to have no significant direct effect on 1-year mortality. The higher unadjusted mortality observed among patients with acute MI and anemia is probably the result of older age, higher comorbidity, and more left ventricular dysfunction.
BACKGROUND: Limited data are available on the effect of anemia on mortality in patients with acute myocardial infarction (MI). METHODS: We examined the association of anemia with mortality at 1 year among 30,341 patients hospitalized with acute MI in 1986 (prethrombolytic era, n = 15,584) and 1996 (thrombolytic era, n = 14,757). The records were obtained from the Myocardial Infarction Data Acquisition System, a database of all patients with MI admitted to nonfederal hospitals in New Jersey. RESULTS:Anemia was present in 996 patients (6.4%) in 1986 and 1510 patients (10.2%, P <.0001) in 1996. In both years, patients with anemia were older, more frequently female and nonwhite, and more likely to have left ventricular dysfunction, non-Q MI and coronary artery bypass graft. In addition, in 1996, patients with anemia were more likely to undergo percutaneous transluminal coronary angioplasty and less likely to have a history of MI. One-year mortality was lower overall in 1996 compared with 1986 (1996 23.6%, 95% CI 22.9-24.3 vs 1986 24.9%, 95% CI 24.2-25.6, P =.0001). In both years, patients with anemia had significantly higher unadjusted risk for 1-year mortality (RR = 1.40, P =.0001 in both years). However, after controlling for demographics, left ventricular dysfunction, arrhythmias, Q versus non-Q MI, comorbid conditions, and revascularization procedures in a multivariable regression model, 1-year mortality in the anemia group was similar to the nonanemia group in both years. CONCLUSION: In the Myocardial Infarction Data Acquisition System database, anemia appears to have no significant direct effect on 1-year mortality. The higher unadjusted mortality observed among patients with acute MI and anemia is probably the result of older age, higher comorbidity, and more left ventricular dysfunction.
Authors: Christopher B Arant; Timothy R Wessel; Paul M Ridker; Marian B Olson; Steven E Reis; B Delia Johnson; Barry L Sharaf; Daniel F Pauly; Eileen Handberg; Issam Zineh; George Sopko; Sheryl F Kelsey; C Noel Bairey Merz; Carl J Pepine Journal: Clin Cardiol Date: 2009-05 Impact factor: 2.882
Authors: Andre Pascal Kengne; Sébastien Czernichow; Mark Hamer; G David Batty; Emmanuel Stamatakis Journal: PLoS One Date: 2012-08-02 Impact factor: 3.240
Authors: David H Shu; Thomas P P Ransom; Colleen M O'Connell; Jafna L Cox; Stephanie M Kaiser; Shirl A Gee; Richard C Rowe; Ehud Ur; Syed Ali Imran Journal: Cardiovasc Diabetol Date: 2006-04-07 Impact factor: 9.951