BACKGROUND: The contribution of antibiotic prophylaxis to reduce surgical wound infection and endometritis after cesarean section is well-known. Despite the knowledge about the effectiveness of antibiotic prophylaxis with this procedure, the administrative regimens are often inappropriate. METHODS: The use of antibiotic prophylaxis in cesarean section was evaluated in a reference school hospital. Data were collected from medical records, and they correspond to the 9-month observation during 1995 and 1996. RESULTS: The cesarean section rate was 26.4% in this period. The total procedures observed was 587. Antibiotic prophylaxis was prescribed in 358 procedures (61%). Cephalothin was the most prescribed drug (98.6%), with a regimen of 2 g intravenously after clamping of the umbilical cord and 2 more doses of 1g every 6 hours. Antibiotic prophylaxis was indicated more frequently in patients younger than 30 years and in those with rupture of membranes for more than 6 hours; such differences were significant (P <.05 and P <.00001, respectively). CONCLUSION: The prescribers met the hospital guidelines for antibiotic prophylaxis in only 37.1% of the cesarean sections performed.
BACKGROUND: The contribution of antibiotic prophylaxis to reduce surgical wound infection and endometritis after cesarean section is well-known. Despite the knowledge about the effectiveness of antibiotic prophylaxis with this procedure, the administrative regimens are often inappropriate. METHODS: The use of antibiotic prophylaxis in cesarean section was evaluated in a reference school hospital. Data were collected from medical records, and they correspond to the 9-month observation during 1995 and 1996. RESULTS: The cesarean section rate was 26.4% in this period. The total procedures observed was 587. Antibiotic prophylaxis was prescribed in 358 procedures (61%). Cephalothin was the most prescribed drug (98.6%), with a regimen of 2 g intravenously after clamping of the umbilical cord and 2 more doses of 1g every 6 hours. Antibiotic prophylaxis was indicated more frequently in patients younger than 30 years and in those with rupture of membranes for more than 6 hours; such differences were significant (P <.05 and P <.00001, respectively). CONCLUSION: The prescribers met the hospital guidelines for antibiotic prophylaxis in only 37.1% of the cesarean sections performed.
Authors: Noel T Mueller; Hakdong Shin; Aline Pizoni; Isabel C Werlang; Ursula Matte; Marcelo Z Goldani; Helena A S Goldani; Maria G Dominguez-Bello Journal: Genes (Basel) Date: 2017-12-04 Impact factor: 4.096