OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 micro M (SD=11.8) in patients with schizophrenia compared with 10.6 micro M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness.
OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 micro M (SD=11.8) in patients with schizophrenia compared with 10.6 micro M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness.
Authors: Manuel Carrasco; Luis G Rabaneda; Maribel Murillo-Carretero; Sylvia Ortega-Martínez; María L Martínez-Chantar; Ashwin Woodhoo; Zigmund Luka; Conrad Wagner; Shelly C Lu; José M Mato; Juan A Micó; Carmen Castro Journal: Hippocampus Date: 2014-04-08 Impact factor: 3.899
Authors: Ji Hae Kim; Jung Ok Lee; Soo Kyung Lee; Ji Wook Moon; Ga Young You; Su Jin Kim; Sun-Hwa Park; Ji Man Park; Se Young Lim; Pann-Ghill Suh; Kyung-Ok Uhm; Min Seok Song; Hyeon Soo Kim Journal: J Biol Chem Date: 2010-12-30 Impact factor: 5.157
Authors: David P Gavin; Cherise Rosen; Kayla Chase; Dennis R Grayson; Nguwah Tun; Rajiv P Sharma Journal: J Psychiatry Neurosci Date: 2009-05 Impact factor: 6.186
Authors: Vicki L Ellingrod; Del D Miller; Stephan F Taylor; Jessica Moline; Timothy Holman; Jane Kerr Journal: Schizophr Res Date: 2007-10-31 Impact factor: 4.939