Literature DB >> 12359325

No reduction with ageing of the number of myenteric neurons in benzalkonium chloride treated rats.

S B Garcia1, M M P Demarzo, W S Vinhadeli, M A Llorach-Velludo, J Zoteli, C F P S Herrero, S Zucoloto.   

Abstract

The number of myenteric neurons may be reduced by topical serosal application of benzalkonium chloride (BAC). We studied the effects of ageing in the population of neurons that survive after the application of BAC. Ten treated and ten control animals were killed at intervals of 2, 6, 12 and 18 months after the surgery. We performed myenteric neurons counting in serially cut histological preparations of the descending colon. The control animals revealed a continuous loss of myenteric neurons number with increasing of age. Interestingly, contrary to control animals, the BAC-treated rats presented no neuron loss with ageing at any experimental time. The reasons for their survival with ageing could be related to a neuroplasticity phenomenon.

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Year:  2002        PMID： 12359325     DOI： 10.1016/s0304-3940(02)00832-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

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  6 in total

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