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Literature DB >> 12358912

Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38- primitive haematopoietic progenitors.

Mohamad Mohty¹, Daniel Isnardon, Norbert Vey, Francine Brière, Didier Blaise, Daniel Olive, Béatrice Gaugler.

Abstract

Myeloid and plasmacytoid dendritic cells (MDC, PDC) play a key role in the initiation of immune responses. We found a reduction of DC subsets among 20 chronic myeloid leukaemia (CML) patients in chronic phase (MDC, mean, 0.10% +/- 0.10, P = 0.02; PDC, mean, 0.11% +/- 0.08, P = 0.006 versus controls). The maintenance of blood DC correlated with the presence of high percentages of circulating CD34+/CD38- progenitors that were able to give rise in vitro to CD1a+ DC. The reduced DC numbers may contribute to leukaemia escape from immune control and restoration of DC may be a goal for CML immunotherapy.

Entities: Disease Gene Species

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Year: 2002 PMID： 12358912 DOI： 10.1046/j.1365-2141.2002.03831.x

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

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Cited

12 in total

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4. Chronic Myelocytic Leukemia (CML) Patient-Derived Dendritic Cells Transfected with Autologous Total RNA Induces CML-Specific Cytotoxicity.

Authors: Li Yu; Ting Hu; Tian Zou; Qingzhi Shi; Guoan Chen
Journal: Indian J Hematol Blood Transfus Date: 2016-01-21 Impact factor: 0.900

Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38- primitive haematopoietic progenitors.

Review 1. The plasmacytoid monocyte/interferon producing cells.

Review 2. Regulation of myelopoiesis by the transcription factor IRF8.

3. Low expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in non-Hodgkin lymphoma and a significant correlation with β2-microglobulin.

4. Chronic Myelocytic Leukemia (CML) Patient-Derived Dendritic Cells Transfected with Autologous Total RNA Induces CML-Specific Cytotoxicity.

Review 5. Therapy Resistance and Disease Progression in CML: Mechanistic Links and Therapeutic Strategies.

Review 6. Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.

Review 7. Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission.

Review 8. Can Dendritic Cell Vaccination Prevent Leukemia Relapse?

9. Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4.

Review 10. Dendritic cell-based immunotherapy for myeloid leukemias.