| Literature DB >> 12358520 |
Natalie A Dales1, Alexandra E Gould, James A Brown, Emily F Calderwood, Bing Guan, Charles A Minor, James M Gavin, Paul Hales, Virendar K Kaushik, Michael Stewart, Peter J Tummino, Chad S Vickers, Timothy D Ocain, Michael A Patane.
Abstract
Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized.Entities:
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Year: 2002 PMID： 12358520 DOI： 10.1021/ja0277226
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419