BACKGROUND AND AIM OF THE STUDY: The incidence and severity of certain infections appear to be increased in patients with diabetes mellitus (DM). The study aim was to evaluate the effect of DM on short- and long-term outcome in patients with active infective endocarditis (IE). METHODS: A total of 151 patients with IE was included and followed up for a mean of 3.1 years. Of these patients, 13 (9%) were diabetics. The outcome of patients with or without DM was compared at short-term (in-hospital) and long-term follow up. RESULTS: Patients with DM were older (66 +/- 11 versus 50 +/- 19 years, p < 0.01) and had a lower frequency of intravenous drug abuse (0 versus 30%, p <0.01) and tricuspid valve involvement (0 versus 20%, p = 0.02) than non-DM patients. Mortality was higher in DM patients both in hospital (31% versus 15%, p = NS) and at a mean follow up of 3.1 years (54% versus 31%, p = 0.002). DM patients also had a significantly higher rate of cardiac failure (69% versus 38%, p = 0.03) and renal failure (62% versus 20%, p <0.01) during hospitalization. Incidences of anatomic complications (abscess, pseudoaneurysm) (15.4% versus 20.3%), valve rupture or perforation (7.7% versus 16.7%) and need for surgical repair (46.2% versus 45.7%) were similar in both DM and non-DM patients. DM, without secondary pathology like renal failure, did not appear to be an independent risk factor for mortality at either short- or long-term follow up. CONCLUSION: Although mortality and morbidity in IE were greater in DM than in non-DM patients, diabetes itself does not constitute an independent risk factor.
BACKGROUND AND AIM OF THE STUDY: The incidence and severity of certain infections appear to be increased in patients with diabetes mellitus (DM). The study aim was to evaluate the effect of DM on short- and long-term outcome in patients with active infective endocarditis (IE). METHODS: A total of 151 patients with IE was included and followed up for a mean of 3.1 years. Of these patients, 13 (9%) were diabetics. The outcome of patients with or without DM was compared at short-term (in-hospital) and long-term follow up. RESULTS:Patients with DM were older (66 +/- 11 versus 50 +/- 19 years, p < 0.01) and had a lower frequency of intravenous drug abuse (0 versus 30%, p <0.01) and tricuspid valve involvement (0 versus 20%, p = 0.02) than non-DMpatients. Mortality was higher in DMpatients both in hospital (31% versus 15%, p = NS) and at a mean follow up of 3.1 years (54% versus 31%, p = 0.002). DMpatients also had a significantly higher rate of cardiac failure (69% versus 38%, p = 0.03) and renal failure (62% versus 20%, p <0.01) during hospitalization. Incidences of anatomic complications (abscess, pseudoaneurysm) (15.4% versus 20.3%), valve rupture or perforation (7.7% versus 16.7%) and need for surgical repair (46.2% versus 45.7%) were similar in both DM and non-DMpatients. DM, without secondary pathology like renal failure, did not appear to be an independent risk factor for mortality at either short- or long-term follow up. CONCLUSION: Although mortality and morbidity in IE were greater in DM than in non-DMpatients, diabetes itself does not constitute an independent risk factor.
Authors: S Leone; V Ravasio; E Durante-Mangoni; M Crapis; G Carosi; P G Scotton; N Barzaghi; M Falcone; P Chinello; M B Pasticci; P Grossi; R Utili; P Viale; M Rizzi; F Suter Journal: Infection Date: 2012-06-19 Impact factor: 3.553
Authors: Z A Kanafani; W M Kourany; V G Fowler; D P Levine; G A Vigliani; M Campion; D E Katz; G R Corey; H W Boucher Journal: Eur J Clin Microbiol Infect Dis Date: 2009-12 Impact factor: 3.267
Authors: María Isabel Biezma; Patricia Muñoz; Sofía De la Villa; Mª Carmen Fariñas-Álvarez; Francisco Arnáiz de Las Revillas; Encarnación Gutierrez-Carretero; Arístides De Alarcón; Raquel Rodríguez-García; Jaume Llopis; Miguel Ángel Goenaga; Andrea Gutierrez-Villanueva; Antonio Plata; Laura Vidal; Manuel Martínez-Sellés Journal: J Clin Med Date: 2022-05-09 Impact factor: 4.241
Authors: Pascal M Dohmen; Christian Binner; Meinhart Mende; Piroze Daviewala; Christian D Etz; Michael Andrew Borger; Martin Misfeld; Sandra Eifert; Friedrich Wilhelm Mohr Journal: Med Sci Monit Date: 2016-07-18