Literature DB >> 12357400

Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.

Cristina Gaspar Marques1, Madalena Pedro, M Fátima A Simões, Maria São José Nascimento, Madalena M M Pinto, Benjamín Rodríguez.   

Abstract

Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.

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Year:  2002        PMID： 12357400     DOI： 10.1055/s-2002-34407

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

1.  Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities.

Authors:  Diogo Matias; Marisa Nicolai; Ana Sofia Fernandes; Nuno Saraiva; Joana Almeida; Lucília Saraiva; Célia Faustino; Ana María Díaz-Lanza; Catarina P Reis; Patrícia Rijo
Journal:  Biomolecules       Date:  2019-05-08

2.  Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones.

Authors:  Vera M S Isca; Milan Sencanski; Nenad Filipovic; Daniel J V A Dos Santos; Ana Čipak Gašparović; Lucília Saraíva; Carlos A M Afonso; Patrícia Rijo; Alfonso T García-Sosa
Journal:  Int J Mol Sci       Date:  2020-05-23       Impact factor: 5.923

3.  Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors.

Authors:  Catarina Garcia; Vera M S Isca; Filipe Pereira; Carlos M Monteiro; Epole Ntungwe; Francisco Sousa; Jelena Dinic; Suvi Holmstedt; Amílcar Roberto; Ana Díaz-Lanza; Catarina P Reis; Milica Pesic; Nuno R Candeias; Ricardo J Ferreira; Noélia Duarte; Carlos A M Afonso; Patrícia Rijo
Journal:  Front Pharmacol       Date:  2020-11-17       Impact factor: 5.810

Review 4.  Abietane Diterpenes of the Genus Plectranthus sensu lato.

Authors:  Mária Gáborová; Karel Šmejkal; Renata Kubínová
Journal:  Molecules       Date:  2021-12-28       Impact factor: 4.411

Review 5.  Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities.

Authors:  Ana Ribeirinha Antão; Gabrielle Bangay; Eva María Domínguez-Martín; Ana María Díaz-Lanza; Patrícia Ríjo
Journal:  Front Pharmacol       Date:  2021-11-30       Impact factor: 5.810

6.  Anticancer Properties of Plectranthus ornatus-Derived Phytochemicals Inducing Apoptosis via Mitochondrial Pathway.

Authors:  Przemysław Sitarek; Ewelina Synowiec; Tomasz Kowalczyk; Gabrielle Bangay; Tomasz Śliwiński; Laurent Picot; Salvatore Princiotto; Patricia Rijo
Journal:  Int J Mol Sci       Date:  2022-10-01       Impact factor: 6.208

7.  In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr.

Authors:  Ramzi A Mothana; Mansour S Al-Said; Nawal M Al-Musayeib; Ali A El Gamal; Shaza M Al-Massarani; Adnan J Al-Rehaily; Majed Abdulkader; Louis Maes
Journal:  Int J Mol Sci       Date:  2014-05-12       Impact factor: 5.923

8.  Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara.

Authors:  Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan; Sadasivam Mathusalini; Palathurai Subramanium Mohan
Journal:  Pharmacognosy Res       Date:  2016 Jul-Sep

9.  Parvifloron D from Plectranthus strigosus: Cytotoxicity Screening of Plectranthus spp. Extracts.

Authors:  Catarina Garcia; Epole Ntungwe; Ana Rebelo; Cláudia Bessa; Tijana Stankovic; Jelena Dinic; Ana Díaz-Lanza; Catarina P Reis; Amílcar Roberto; Paula Pereira; Maria-João Cebola; Lucília Saraiva; Milica Pesic; Noélia Duarte; Patrícia Rijo
Journal:  Biomolecules       Date:  2019-10-17
  9 in total

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