Literature DB >> 12357344

Variations on a theme: the alternate translocations in APL.

R L Redner1.   

Abstract

The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR. In this review we will discuss these variant translocations, and discuss the insights that we have gained from their study.

Entities:  

Mesh：

Year:  2002        PMID： 12357344     DOI： 10.1038/sj.leu.2402720

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  36 in total

1.  The leukemic oncoprotein NPM1-RARA inhibits TP53 activity.

Authors:  Erin M Swaney; Anuja Chattopadhyay; Irina Abecassis; Elizabeth A Rush; Robert L Redner
Journal:  Leuk Lymphoma       Date:  2016-01-12

Review 2.  Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis.

Authors:  Daniel E Johnson
Journal:  Adv Enzyme Regul       Date:  2007-11-19

3.  Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.

Authors:  June Li; Daniel P Sejas; Sandeep Burma; David J Chen; Qishen Pang
Journal:  Carcinogenesis       Date:  2007-02-02       Impact factor: 4.944

4.  A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion.

Authors:  Christopher A Miller; Christopher Tricarico; Zachary L Skidmore; Geoffrey L Uy; Yi-Shan Lee; Anjum Hassan; Michelle D O'Laughlin; Heather Schmidt; Ling Tian; Eric J Duncavage; Malachi Griffith; Obi L Griffith; John S Welch; Lukas D Wartman
Journal:  Blood Adv       Date:  2018-06-12

Review 5.  How I treat children and adolescents with acute promyelocytic leukaemia.

Authors:  Oussama Abla; Raul C Ribeiro
Journal:  Br J Haematol       Date:  2013-09-30       Impact factor: 6.998

6.  An optimized technology platform for the rapid multiplex molecular analysis of genetic alterations associated with leukemia.

Authors:  Fei Ye; Walairat Laosinchai-Wolf; Emmanuel Labourier
Journal:  Cancer Genet       Date:  2012-09-29

7.  Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21).

Authors:  Kazumi Suzukawa; Seiichi Shimizu; Noriko Nemoto; Naoko Takei; Tomohiko Taki; Toshiro Nagasawa
Journal:  Int J Hematol       Date:  2005-07       Impact factor: 2.490

8.  The PML domain of PML-RARα blocks senescence to promote leukemia.

Authors:  Katharina Korf; Harald Wodrich; Alexander Haschke; Corinne Ocampo; Lena Harder; Friederike Gieseke; Annika Pollmann; Kevin Dierck; Sebastian Prall; Hannah Staege; Hui Ma; Martin A Horstmann; Ronald M Evans; Thomas Sternsdorf
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-04       Impact factor: 11.205

9.  Effect of all trans retinoic acid on lysosomal alpha-D-mannosidase activity in HL-60 cell: correlation with HL-60 cells differentiation.

Authors:  Leda Racanicchi; Pia Montanucci; Giuseppe P P Basta; Alessandra Pensato; Valentina Conti; Riccardo Calafiore
Journal:  Mol Cell Biochem       Date:  2007-09-26       Impact factor: 3.396

Review 10.  PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia.

Authors:  Kazunori Ohnishi
Journal:  Int J Clin Oncol       Date:  2007-10-22       Impact factor: 3.402
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