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Literature DB >> 12354558

Functional and evolutionary analysis of a eukaryotic parasitic genome.

Christian P Vivarès¹, Manolo Gouy, Fabienne Thomarat, Guy Méténier.

Abstract

The DNA sequences of the 11 linear chromosomes of the approximately 2.9 Mbp genome of Encephalitozoon cuniculi, an obligate intracellular parasite of mammals, include approximately 2000 putative protein-coding genes. The compactness of this genome is associated with the length reduction of various genes. Essential functions are dependent on a minimal set of genes. Phylogenetic analysis supports the hypotheses that microsporidia are related to fungi and have retained a mitochondrion-derived organelle, the mitosome.

Entities: Species

Mesh：

Substances：
Protozoan Proteins

Year: 2002 PMID： 12354558 DOI： 10.1016/s1369-5274(02)00356-9

Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934

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Cited

22 in total

1. Covariation of mitochondrial genome size with gene lengths: evidence for gene length reduction during mitochondrial evolution.

Authors: André Schneider; Dieter Ebert
Journal: J Mol Evol Date: 2004-07 Impact factor: 2.395

Review 2. Microsporidiosis: current status.

Authors: Elizabeth S Didier; Louis M Weiss
Journal: Curr Opin Infect Dis Date: 2006-10 Impact factor: 4.915

Functional and evolutionary analysis of a eukaryotic parasitic genome.

1. Covariation of mitochondrial genome size with gene lengths: evidence for gene length reduction during mitochondrial evolution.

Review 2. Microsporidiosis: current status.

Review 3. Simplicity and complexity of microsporidian genomes.

Review 4. Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansion.

5. A high frequency of overlapping gene expression in compacted eukaryotic genomes.

Review 6. Mitochondria, hydrogenosomes and mitosomes: products of evolutionary tinkering!

Review 7. Multiple secondary origins of the anaerobic lifestyle in eukaryotes.

8. Comparative analysis of the ribosomal components of the hydrogenosome-containing protist, Trichomonas vaginalis.

9. Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees.

10. Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi.