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Literature DB >> 12354358

New markers for cancer detection.

Abstract

Circulating tumor nucleic acids in blood have been demonstrated to reflect the biologic characteristics of tumors. During tumor progression, aberrant DNA methylation can lead to transcriptional silencing of tumor suppressor genes, DNA repair genes, and metastasis-inhibitor genes. Hypermethylation of multiple genes, detectable in the blood of cancer patients, has demonstrated increasing promise as a specific and sensitive molecular marker for detecting and monitoring cancer. In addition to these epigenetic markers, a number of mRNA markers may also enable cancer detection in the blood of patients with different cancer types. Quantification of circulating tumor cell mRNAs in cancer patients appears to be useful for monitoring cancer progression and response to treatment. DNA methylation markers and mRNA markers in the blood may open up diagnostic and prognostic possibilities.

Entities: Disease Species

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Year: 2002 PMID： 12354358 DOI： 10.1007/s11912-002-0058-3

Source DB: PubMed Journal: Curr Oncol Rep ISSN： 1523-3790 Impact factor: 5.075

51 in total

1. Quantitative analysis of circulating tumor cells in peripheral blood of osteosarcoma patients using osteoblast-specific messenger RNA markers: a pilot study.

Authors: I H Wong; A T Chan; P J Johnson
Journal: Clin Cancer Res Date: 2000-06 Impact factor: 12.531

2. Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia.

Authors: N H Silva; G Pimenta; W A Pulcheri; M V Fournier; N Spector; M G da Costa Carvalho
Journal: Oncol Rep Date: 2001 May-Jun Impact factor: 3.906

3. Microsatellite alterations in plasma DNA of small cell lung cancer patients.

Authors: X Q Chen; M Stroun; J L Magnenat; L P Nicod; A M Kurt; J Lyautey; C Lederrey; P Anker
Journal: Nat Med Date: 1996-09 Impact factor: 53.440

4. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer.

Authors: W M Grady; A Rajput; J D Lutterbaugh; S D Markowitz
Journal: Cancer Res Date: 2001-02-01 Impact factor: 12.701

5. Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma.

Authors: C Maesawa; G Tamura; S Nishizuka; S Ogasawara; K Ishida; M Terashima; K Sakata; N Sato; K Saito; R Satodate
Journal: Cancer Res Date: 1996-09-01 Impact factor: 12.701

6. Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tumor progression.

Authors: I H Wong; W Yeo; A T Chan; P J Johnson
Journal: Cancer Lett Date: 2001-01-10 Impact factor: 8.679

New markers for cancer detection.

1. Quantitative analysis of circulating tumor cells in peripheral blood of osteosarcoma patients using osteoblast-specific messenger RNA markers: a pilot study.

2. Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia.

3. Microsatellite alterations in plasma DNA of small cell lung cancer patients.

4. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer.

5. Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma.

6. Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tumor progression.

7. Molecular detection of genetic alterations in the serum of colorectal cancer patients.

8. Mutation spectrum of the retinoblastoma gene in osteosarcomas.

9. Well-differentiated hepatocellular carcinoma: clinicopathological features and results of hepatic resection.

10. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals.

1. CHP2 gene expression and quantitation in Egyptian patients with acute leukemia.