BACKGROUND: Memory declines were evaluated with an adaptation of the Cued Recall Test (CRT) in 19 adults with Down's syndrome (DS) with mild or moderate intellectual disability (ID) who were at an early-stage of dementia of the Alzheimer type (DAT), and their performance was compared to peer groups of 75 adults with DS and 66 adults with ID without DS who were not suspected of functional declines. METHOD: The CRT consisted of a training period in which 12 items were presented, four at a time, with each item accompanied by a unique category cue. The testing phase consisted of three trials which generated two measures, a free recall score (FRS; spontaneous recall of the list of 12 items) and a total score (TS; FRS plus items recalled when the category cue was provided). RESULTS: It was found that a cut-off value of < or = 23 on the TS resulted in a sensitivity of 94.7% and a specificity of 93.9% with a positive predictive value of 81.9% when those individuals with DAT were compared to the participants with ID without DS. Eight of these individuals with DAT had relatively poor performance on the CRT compared to their healthy peers at a baseline when they were not suspected of functional declines, suggesting that memory declines can occur several years prior to the identification of DAT. In addition, 17 participants with DS without a diagnosis of DAT met the criterion for the cut-off score. Longitudinal data and converging measures indicated that there was the possibility that 15 of these individuals are in a 'pre-clinical' stage of decline. CONCLUSION: The usefulness of the CRT as a screening test for early memory deficits for this population needs to be confirmed by following these participants for an extended period of time and by studying an independent sample.
BACKGROUND:Memory declines were evaluated with an adaptation of the Cued Recall Test (CRT) in 19 adults with Down's syndrome (DS) with mild or moderate intellectual disability (ID) who were at an early-stage of dementia of the Alzheimer type (DAT), and their performance was compared to peer groups of 75 adults with DS and 66 adults with ID without DS who were not suspected of functional declines. METHOD: The CRT consisted of a training period in which 12 items were presented, four at a time, with each item accompanied by a unique category cue. The testing phase consisted of three trials which generated two measures, a free recall score (FRS; spontaneous recall of the list of 12 items) and a total score (TS; FRS plus items recalled when the category cue was provided). RESULTS: It was found that a cut-off value of < or = 23 on the TS resulted in a sensitivity of 94.7% and a specificity of 93.9% with a positive predictive value of 81.9% when those individuals with DAT were compared to the participants with ID without DS. Eight of these individuals with DAT had relatively poor performance on the CRT compared to their healthy peers at a baseline when they were not suspected of functional declines, suggesting that memory declines can occur several years prior to the identification of DAT. In addition, 17 participants with DS without a diagnosis of DAT met the criterion for the cut-off score. Longitudinal data and converging measures indicated that there was the possibility that 15 of these individuals are in a 'pre-clinical' stage of decline. CONCLUSION: The usefulness of the CRT as a screening test for early memory deficits for this population needs to be confirmed by following these participants for an extended period of time and by studying an independent sample.
Authors: Warren B Zigman; Darlynne A Devenny; Sharon J Krinsky-McHale; Edmund C Jenkins; Tiina K Urv; Jerzy Wegiel; Nicole Schupf; Wayne Silverman Journal: Int Rev Res Ment Retard Date: 2008-01-01
Authors: E R Wallace; J P Harp; K L Van Pelt; L M Koehl; A M Caban-Holt; A J Anderson-Mooney; G A Jicha; D D Lightner; W C Robertson; E Head; F A Schmitt Journal: J Intellect Disabil Res Date: 2021-11-16
Authors: Susana de Sola; Rafael de la Torre; Gonzalo Sánchez-Benavides; Bessy Benejam; Aida Cuenca-Royo; Laura Del Hoyo; Joan Rodríguez; Silvina Catuara-Solarz; Judit Sanchez-Gutierrez; Ivan Dueñas-Espin; Gimena Hernandez; Jordi Peña-Casanova; Klaus Langohr; Sebastia Videla; Henry Blehaut; Magi Farre; Mara Dierssen Journal: Front Psychol Date: 2015-06-04
Authors: Frances K Wiseman; Tamara Al-Janabi; John Hardy; Annette Karmiloff-Smith; Dean Nizetic; Victor L J Tybulewicz; Elizabeth M C Fisher; André Strydom Journal: Nat Rev Neurosci Date: 2015-08-05 Impact factor: 34.870
Authors: H Diana Rosas; Eugene Hsu; Nathaniel D Mercaldo; Florence Lai; Margaret Pulsifer; David Keator; Adam M Brickman; Julie Price; Michael Yassa; Christy Hom; Sharon J Krinsky-McHale; Wayne Silverman; Ira Lott; Nicole Schupf Journal: Alzheimers Dement (Amst) Date: 2020-11-07