The relationship between the levels of SigA, lactoferrin and alpha(1) proteinase inhibitor in saliva and permanent dentition caries in 15-year-olds.

A group of 15-year-olds were clinically examined for general state of dentition and level of dental caries. Unstimulated whole saliva from the subjects was laboratory tested to determine the levels of lactoferrin, Secretory IgA (SIgA) and alpha1 proteinase inhibitor. A significant relationship was found between the decayed surface index and the levels of lactoferrin, SIgA and alpha1 proteinase inhibitor in the unstimulated saliva. The decayed surface index rose with increases in the levels of lactoferrin, SIgA and alpha1 proteinase inhibitor, the relationship with alpha1 proteinase inhibitor being strongest.