Literature DB >> 12353977

A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic.

Oliver Langer1, Hanspeter Kählig, Karen Zierler-Gould, Jan W Bats, Johann Mulzer.   

Abstract

A cispentacin-derived bicyclic beta-amino acid (Bic) has been synthesized and incorporated into the 6-position of GnRH. The new GnRH analogue has been characterized with respect to its structure in solution and its activity and affinity toward the human GnRH receptor.

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Year:  2002        PMID: 12353977     DOI: 10.1021/jo025857o

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets.

Authors:  Matthew W McCarthy; Thomas J Walsh
Journal:  Int J Mol Sci       Date:  2018-03-19       Impact factor: 5.923

2.  Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids.

Authors:  Takayuki Katoh; Toru Sengoku; Kunio Hirata; Kazuhiro Ogata; Hiroaki Suga
Journal:  Nat Chem       Date:  2020-08-24       Impact factor: 24.427

  2 in total

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