Literature DB >> 12353360

Conflict of interest as seen from a researcher's perspective.

Arrigo Schieppati1, Norberto Perico, Giuseppe Remuzzi.   

Abstract

The continuous growth of the pharmaceutical industry is expected to require a considerable output of new drugs, with speedy development and approval processes. This profit-driven expansion of the drug market may broaden the already established erosion of the role of academia in favor of commercial clinical research organizations. Less and less control on the clinical trial design, its conduct and the resulting publication[s] is the likely consequence. Academic medicine and governments should find means to sustain the development of independent clinical research.

Keywords:  Biomedical and Behavioral Research

Mesh:

Year:  2002        PMID: 12353360     DOI: 10.1007/s11948-002-0053-y

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN: 1353-3452            Impact factor:   3.525


  19 in total

1.  Uneasy alliance--clinical investigators and the pharmaceutical industry.

Authors:  T Bodenheimer
Journal:  N Engl J Med       Date:  2000-05-18       Impact factor: 91.245

2.  Is academic medicine for sale?

Authors:  M Angell
Journal:  N Engl J Med       Date:  2000-05-18       Impact factor: 91.245

3.  Maintaining the integrity of the clinical evidence base.

Authors:  J Quick
Journal:  Bull World Health Organ       Date:  2001       Impact factor: 9.408

4.  Relationships between authors of clinical practice guidelines and the pharmaceutical industry.

Authors:  Niteesh K Choudhry; Henry Thomas Stelfox; Allan S Detsky
Journal:  JAMA       Date:  2002-02-06       Impact factor: 56.272

5.  Managing conflicts of interest in the conduct of clinical trials.

Authors:  Karine Morin; Herbert Rakatansky; Frank A Riddick; Leonard J Morse; John M O'Bannon; Michael S Goldrich; Priscilla Ray; Matthew Weiss; Robert M Sade; Monique A Spillman
Journal:  JAMA       Date:  2002-01-02       Impact factor: 56.272

6.  A logistic-regression model provides novel guidelines to maximize the anti-acute rejection properties of cyclosporine with a minimum of toxicity.

Authors:  A Perna; E Gotti; E de Bernardis; N Perico; G Remuzzi
Journal:  J Am Soc Nephrol       Date:  1996-05       Impact factor: 10.121

7.  A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis.

Authors:  P A Rochon; J H Gurwitz; R W Simms; P R Fortin; D T Felson; K L Minaker; T C Chalmers
Journal:  Arch Intern Med       Date:  1994-01-24

8.  The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes.

Authors:  H H Parving; H Lehnert; J Bröchner-Mortensen; R Gomis; S Andersen; P Arner
Journal:  N Engl J Med       Date:  2001-09-20       Impact factor: 91.245

Review 9.  Are me-too drugs justified?

Authors:  S Garattini
Journal:  J Nephrol       Date:  1997 Nov-Dec       Impact factor: 3.902

10.  Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group.

Authors:  L Hansson; A Zanchetti; S G Carruthers; B Dahlöf; D Elmfeldt; S Julius; J Ménard; K H Rahn; H Wedel; S Westerling
Journal:  Lancet       Date:  1998-06-13       Impact factor: 79.321

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