Literature DB >> 12352342

Vesicoureteral reflux and clinical outcomes in infants with prenatally detected hydronephrosis.

M Michele Brophy1, Paul F Austin, Yan Yan, Douglas E Coplen.   

Abstract

PURPOSE: We evaluate the incidence of vesicoureteral reflux and urinary tract infections in infants with prenatally detected hydronephrosis.
MATERIALS AND METHODS: We retrospectively reviewed the charts of children referred to our hospital for evaluation of prenatally detected hydronephrosis between 1992 and 1998. Measured variables included ultrasound and voiding cystourethrogram findings, and infectious and clinical reflux outcomes.
RESULTS: Vesicoureteral reflux was identified in 40 of 234 infants (21%), including 24% of males and 13% of females. A significant correlation was found between the degree of hydronephrosis and incidence of reflux. Urinary tract infections were uncommon and identified in 7.5% of children on prevention for reflux and 4% with normal voiding cystourethrogram. In the majority (58%) of cases reflux resolved with medical management.
CONCLUSIONS: The incidence of reflux increases with greater degrees of sonographic dilatation but a normal ultrasound does not exclude reflux and, therefore, voiding cystourethrogram is recommended in all children with prenatally detected hydronephrosis. Since urinary tract infections are uncommon with prevention, antibiotics should be continued until reflux resolves and/or hydronephrosis significantly improves.

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Year:  2002        PMID: 12352342     DOI: 10.1097/01.ju.0000026907.65728.6e

Source DB:  PubMed          Journal:  J Urol        ISSN: 0022-5347            Impact factor:   7.450


  15 in total

Review 1.  Management of fetal hydronephrosis.

Authors:  Jenny Yiee; Duncan Wilcox
Journal:  Pediatr Nephrol       Date:  2007-08-02       Impact factor: 3.714

2.  Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary?

Authors:  Sofia Visuri; Reetta Kivisaari; Timo Jahnukainen; Seppo Taskinen
Journal:  Pediatr Nephrol       Date:  2018-04-07       Impact factor: 3.714

3.  To V(CUG) or not to V(CUG) in infants with prenatal hydronephrosis?

Authors:  Sisir Botta; Hillary L Copp
Journal:  J Urol       Date:  2014-06-18       Impact factor: 7.450

4.  Prenatally detected, unilateral, high-grade hydronephrosis: Can we predict the natural history?

Authors:  Osama M Sarhan; Ahmed El Helaly; Abdul Hakim Al Otay; Mustafa Al Ghanbar; Ziad Nakshabandi
Journal:  Can Urol Assoc J       Date:  2017-12-22       Impact factor: 1.862

5.  Mild hydronephrosis in newborns and infants: can ultrasound predict the presence of vesicoureteral reflux.

Authors:  Teresa Berrocal; Inmaculada Pinilla; Julia Gutiérrez; Consuelo Prieto; Luis de Pablo; María-Luisa Del Hoyo
Journal:  Pediatr Nephrol       Date:  2006-09-12       Impact factor: 3.714

Review 6.  Applying the ALARA concept to the evaluation of vesicoureteric reflux.

Authors:  Richard S Lee; David A Diamond; Jeanne S Chow
Journal:  Pediatr Radiol       Date:  2006-09

7.  Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis.

Authors:  Zachary N Gordon; Daryl J McLeod; Christina B Ching; Daniel B Herz; D Gregory Bates; Brian Becknell; Seth A Alpert
Journal:  J Pediatr Urol       Date:  2016-05-27       Impact factor: 1.830

Review 8.  Current management of antenatal hydronephrosis.

Authors:  Kleiton G R Yamaçake; Hiep T Nguyen
Journal:  Pediatr Nephrol       Date:  2012-07-27       Impact factor: 3.714

9.  Urinary tract infection in the newborn: clinical and radio imaging studies.

Authors:  José B López Sastre; Antonio Ramos Aparicio; Gil D Coto Cotallo; Belén Fernández Colomer; Manuel Crespo Hernández
Journal:  Pediatr Nephrol       Date:  2007-07-31       Impact factor: 3.714

10.  Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism.

Authors:  Hang Wang; Qinggang Li; Juan Liu; Cathy Mendelsohn; David J Salant; Weining Lu
Journal:  PLoS One       Date:  2011-09-20       Impact factor: 3.240

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